P4HB anticorps (AA 20-509)

N° du produit ABIN7141113

L’anticorps Lapin Polyclonal anti-P4HB a été validé pour ELISA. Il convient pour détecter P4HB dans des échantillons de Chinese Hamster.

Aperçu rapide pour P4HB anticorps (AA 20-509) (ABIN7141113)

Antigène: P4HB (Prolyl 4-Hydroxylase, beta Polypeptide (P4HB))

Reactivité: Chinese Hamster

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp P4HB est non-conjugé

Application: ELISA

Détail du produit anti-P4HB anticorps

Épitope: AA 20-509

Fonction: P4HB Antibody

Purification: Protein G purified

Pureté: >95 %

Immunogène: Recombinant Cricetulus griseus Protein disulfide-isomerase protein (20-509AA)

Isotype: IgG

Information d'application

Indications d'application: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Stockage

Format: Liquid

Buffer: Preservative: 0.03 % Proclin 300
Constituents: 50 % Glycerol, 0.01M PBS, PH 7.4

Agent conservateur: ProClin

Précaution d'utilisation: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: -20 °C,-80 °C

Stockage commentaire: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Détails sur P4HB

Antigène: P4HB (Prolyl 4-Hydroxylase, beta Polypeptide (P4HB))

Autre désignation: P4HB

Sujet:

Background: This multifunctional protein catalyzes the formation, breakage and rearrangement of disulfide bonds. At the cell surface, seems to act as a reductase that cleaves disulfide bonds of proteins attached to the cell. May therefore cause structural modifications of exofacial proteins. Inside the cell, seems to form/rearrange disulfide bonds of nascent proteins. At high concentrations, functions as a chaperone that inhibits aggregation of misfolded proteins. At low concentrations, facilitates aggregation (anti-chaperone activity). May be involved with other chaperones in the structural modification of the TG precursor in hormone biogenesis. Also acts a structural subunit of various enzymes such as prolyl 4-hydroxylase and microsomal triacylglycerol transfer protein MTTP. Receptor for LGALS9, the interaction retains P4HB at the cell surface of Th2 T helper cells, increasing disulfide reductase activity at the plasma membrane, altering the plasma membrane redox state and enhancing cell migration.

Aliases: P4HB antibody, PDIA1Protein disulfide-isomerase antibody, PDI antibody, EC 5.3.4.1 antibody, Prolyl 4-hydroxylase subunit beta antibody, p58 antibody

UniProt: Q8R4U2

Pathways: Maintenance of Protein Location, Cell RedoxHomeostasis, Lipid Metabolism